Peptide Libraray

MGS4_V9 (dimer)

General Information

DCTPep ID DCTPep06878

Peptide Name MGS4_V9 (dimer)

Sequence FHAVPQSFYT

Sequence Length 10

UniProt ID Not available

PubChem CID Not available

Origin Synthetic (derived from MGS4)

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
H358	Minimally invasive lung adenocarcinoma	EC50=3.9nM	Streptavidin-R-phycoerythrin or streptavidin-Alexa Fluor 647	1h	1
H1993	Lung adenocarcinoma	EC50=4nM	Streptavidin-R-phycoerythrin or streptavidin-Alexa Fluor 647	1h	1
H1299	Lung large cell carcinoma	EC50=5.8nM	Streptavidin-R-phycoerythrin or streptavidin-Alexa Fluor 647	1h	1
H2009	Lung adenocarcinoma	EC50=6.8nM	Streptavidin-R-phycoerythrin or streptavidin-Alexa Fluor 647	1h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Dimer

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C58H77N13O15

Absent amino acids CDEGIKLMNRW

Theoretical pI 6.74

Acidic residues 0

Basic residues 1

Polar residues 3

Molecular weight (Average) 1196.33

Molecular weight (Monoisotopic) 1195.57

Common amino acids F

Net charge 1

Instability index (II) 115.57

Aliphatic index 39.00

Grand average of hydropathicity (GRAVY) 0.050

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.245

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 36650239

Title Tumor-specific intracellular delivery: peptide-guided transport of a catalytic toxin

Doi 10.1038/s42003-022-04385-7

Year 2023

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available