MGS4_V10 (tetramer)

General Information


DCTPep ID  DCTPep06879

Peptide Name   MGS4_V10 (tetramer)

Sequence  FHAVPQSFYT

Sequence Length  10

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic (derived from MGS4)

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
H1993 Lung adenocarcinoma EC50=1.5nM Streptavidin-R-phycoerythrin or streptavidin-Alexa Fluor 647 1h 1
H1299 Lung large cell carcinoma EC50=2.5nM Streptavidin-R-phycoerythrin or streptavidin-Alexa Fluor 647 1h 1
H2009 Lung adenocarcinoma EC50=3.4nM Streptavidin-R-phycoerythrin or streptavidin-Alexa Fluor 647 1h 1
H358 Minimally invasive lung adenocarcinoma EC50=3.5nM Streptavidin-R-phycoerythrin or streptavidin-Alexa Fluor 647 1h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Tetramer

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C58H77N13O15

Absent amino acids  CDEGIKLMNRW

Theoretical pI  6.74

Acidic residues  0

Basic residues  1

Polar residues  3

Molecular weight (Average)  1196.33

Molecular weight (Monoisotopic)  1195.57

Common amino acids  F

Net charge  1

Instability index (II)  115.57

Aliphatic index  39.00

Grand average of hydropathicity (GRAVY)  0.050

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 1490
  Abs 0.1% (=1 g/l) 1.245

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 36650239

Title  Tumor-specific intracellular delivery: peptide-guided transport of a catalytic toxin

Doi 10.1038/s42003-022-04385-7

Year  2023

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.