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ALA-A2
General Information
DCTPep ID DCTPep06880
Peptide Name ALA-A2
Sequence KLWCKSSQVPQSR
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HT-29 | Colon adenocarcinoma | 55.3 ± 2.7% cell viability=200µM | MTT assay | 24h | 1 |
| A549 | Lung adenocarcinoma | 59.7 ± 1.1% cell viability=200µM | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C67H111N21O19S1
Absent amino acids ADEFGHIMNTY
Theoretical pI 10.06
Acidic residues 0
Basic residues 3
Polar residues 4
Molecular weight (Average) 1546.81
Molecular weight (Monoisotopic) 1545.81
Common amino acids S
Net charge 3
Instability index (II) 122.99
Aliphatic index 52.31
Grand average of hydropathicity (GRAVY) -1.054
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.556, assuming all pairs of Cys residues form cystines
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.556, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 36910465
Title ALA-A2 Is a Novel Anticancer Peptide Inspired by Alpha-Lactalbumin: A Discovery from a Computational Peptide Library, In Silico Anticancer Peptide Screening and In Vitro Experimental Validation
Year 2023
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.