Bleomycin A6
DCTPepD ID DCTPepD0051
Active Ingredients Bleomycin A6
Description A component of the antibiotic bleomycin produced by Streptomyces species, with potential antineoplastic activity. Upon administration, boanmycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals. This causes single- and double-stranded DNA breaks which eventually leads to cell death. Compared to bleomycin, boanmycin appears to have a more favorable toxicity profile.
Synonyms Bleomycin; Bleomycin A6
Disease Squamous Cell Lung Cancer
Classification
Peptide and derivative
Structure Information
Molecular Formula C60H96N20O21S2
Molecular Weight 1497.7
Active Sequence Not available
Sequence Length Not available
Modification Not available
IUPAC Name [(2R,3S,4S,5R,6R)-2-[(2R,3S,4S,5S,6S)-2-[(1R,2S)-2-[[6-amino-2-[(1S)-3-amino-1-[[(2S)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[(2R,3S,4S)-5-[[(2S,3R)-1-[2-[4-[4-[3-[4-(3-aminopropylamino)butylamino]propylcarbamoyl]-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hydroxy-4-methyl-5-oxopentan-2-yl]amino]-1-(1H-imidazol-5-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl] carbamate
InChI InChI=1S/C60H96N20O21S2/c1-25-38(77-51(80-49(25)64)30(17-36(63)84)72-18-29(62)50(65)90)55(94)79-40(46(31-19-69-24-73-31)99-59-48(44(88)42(86)34(20-81)98-59)100-58-45(89)47(101-60(66)96)43(87)35(21-82)97-58)56(95)74-27(3)41(85)26(2)52(91)78-39(28(4)83)54(93)71-16-9-37-75-33(23-102-37)57-76-32(22-103-57)53(92)70-15-8-14-68-12-6-5-11-67-13-7-10-61/h19,22-24,26-30,34-35,39-48,58-59,67-68,72,81-83,85-89H,5-18,20-21,61-62H2,1-4H3,(H2,63,84)(H2,65,90)(H2,66,96)(H,69,73)(H,70,92)(H,71,93)(H,74,95)(H,78,91)(H,79,94)(H2,64,77,80)/t26-,27+,28+,29-,30-,34-,35+,39-,40-,41-,42+,43+,44-,45-,46-,47-,48-,58+,59-/m0/s1
InChI_Key FOUFFVYWFNBHHH-YNGSZULRSA-N
SMILES CC1=C(N=C(N=C1C(N[C@@H]([C@H](C2=CN=CN2)O[C@@H]3O[C@H]([C@H]([C@@H]([C@@H]3O[C@H]4O[C@@H]([C@H]([C@@H]([C@@H]4O)OC(N)=O)O)CO)O)O)CO)C(N[C@@H]([C@H]([C@@H](C(N[C@@H]([C@H](O)C)C(NCCC5=NC(C6=NC(C(NCCCNCCCCNCCCN)=O)=CS6)=CS5)=O)=O)C)O)C)=O)=O)[C@@H](NC[C@@H](C(N)=O)N)CC(N)=O)N
External Codes
PubChem CID 9877229
DrugBank Accession Number DB12992
NCI Thesaurus Code C102878
UNII 0B19OCB220 GSRS
CAS 37293-17-7
Drug approval
Drug indication
Bleomycin A6 participated in clinical trials for the treatment of Squamous Cell Lung Cancer.
The drug is not approved.
| ClinicalTrials.gov Identifier | Title | Condition or disease | Phase | Purpose |
|---|---|---|---|---|
| NCT01660399 | Boanmycin Hydrochloride for Injection in Combination With Docetaxel for Patients With Advanced Lung Squamous Cell Carcinoma as Salvage Chemotherapy: a Prospective, Randomized, Parallel and Controlled Clinical Trial | Squamous Cell Lung Cancer | Phase 2 | Treatment |
More clinical information is obtained from ClinicalTrials.gov.
