Corticorelin
DCTPepD ID DCTPepD0064
Active Ingredients Corticorelin
Description Any synthetic therapeutic agent which is chemically identical to or similar to the endogenous human corticotropin-releasing factor (hCRF). Synthesized in the hypothalamus, hCRF stimulates the anterior pituitary gland to secrete adrenocorticotropic hormone (ACTH). In cerebral edema, hCRF acts by impeding the flow of fluid from blood vessels into brain tissue, thereby decreasing edema and stabilizing intracranial pressure. This agent possesses anti-edema properties independent of adrenal gland function.
Synonyms Recombinant Human Corticotropin Releasing Factor; Therapeutic Corticotropin-Releasing Factor; CFR; Corticoliberin
Disease Brain cancer
Classification
Peptide and derivative
Structure Information
Molecular Formula C208H344N60O63S2
Molecular Weight 4757
Active Sequence SEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII
Sequence Length 41
Modification None
Structure
IUPAC Name Not available
InChI Not available
InChI_Key Not available
SMILES Not available
External Codes
PubChem CID 16186200
DrugBank Accession Number DB05394
NCI Thesaurus Code C394
UNII 305OE8862Y GSRS
CAS 86784-80-7
Drug approval
Drug indication
Investigated for use/treatment in brain cancer and neurologic disorders.
The drug is not approved.
| ClinicalTrials.gov Identifier | Title | Condition or disease | Phase | Purpose |
|---|---|---|---|---|
| NCT00088166 | A Phase III Randomized, Double-Blind, Dexamethasone-Sparing Study Comparing Human Corticotropin-Releasing Factor (hCRF) to Placebo for Control of Symptoms Associated With Peritumoral Brain Edema in Patients With Malignant Brain Tumor Who Require Chronic Administration of High-Dose Dexamethasone | Brain Edema; Brain Tumor | Phase 3 | Treatment |
More clinical information is obtained from ClinicalTrials.gov.
