Peptide Libraray

General Information

DCTPep ID DCTPep00112

Peptide Name V1

Sequence CVKVKVKVGSGVKVKVKVC

Sequence Length 19

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane-targeted

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
THP-1	Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia	IC50=45 µM	CellTiter 96 AQueous One Solution assay	1 h	1

Hemolytic Activity Human erythrocytes: 50% Hemolysis=880 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00112

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond Cys1<--->Cys19

N-terminal Modification Acetylization

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C89H167N25O21S2

Absent amino acids ADEFHILMNPQRTWY

Theoretical pI 10.05

Acidic residues 0

Basic residues 6

Polar residues 5

Molecular weight (Average) 1987.58

Molecular weight (Monoisotopic) 1986.22

Common amino acids V

Net charge 6

Instability index (II) -34.87

Aliphatic index 122.11

Grand average of hydropathicity (GRAVY) 0.716

Half Life
1.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.063, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 15328096

Title De novo design of potent antimicrobial peptides

Doi 10.1128/AAC.48.9.3349-3357.2004

Year 2004

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available