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V6
General Information
DCTPep ID DCTPep00117
Peptide Name V6
Sequence CFKFKFKFGSGFKFKFKFC
Sequence Length 19
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | IC50=45 µM | CellTiter 96 AQueous One Solution assay | 1 h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=35 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00117
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys1<--->Cys19
N-terminal Modification Acetylization
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C121H167N25O21S2
Absent amino acids ADEHILMNPQRTVWY
Theoretical pI 10.05
Acidic residues 0
Basic residues 6
Polar residues 5
Molecular weight (Average) 2371.93
Molecular weight (Monoisotopic) 2370.22
Common amino acids F
Net charge 6
Instability index (II) -37.99
Aliphatic index 0.00
Grand average of hydropathicity (GRAVY) 0.126
Half Life
1.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.053, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 15328096
Title De novo design of potent antimicrobial peptides
Doi 10.1128/AAC.48.9.3349-3357.2004
Year 2004
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.