Peptide Libraray

Phylloseptin-L1

General Information

DCTPep ID DCTPep00186

Peptide Name Phylloseptin-L1

Sequence LLGMIPLAISAISALSKL

Sequence Length 18

UniProt ID A0A5Q0MU22 P0DQK9 L0P329

PubChem CID Not available

Origin skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae)

Type Native peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
Hep-G2	Hepatoblastoma; Hepatoblastoma	LC50=35 μM	Cytolytic assays	1 h	1

Hemolytic Activity Human erythrocytes: LC50=200 μM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Cytolytic

Structure Information

PDB ID Not available

Predicted Structure DCTPep00186

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C84H151N19O22S1

Absent amino acids CDEFHNQRTVWY

Theoretical pI 8.75

Acidic residues 0

Basic residues 1

Polar residues 4

Molecular weight (Average) 1811.3

Molecular weight (Monoisotopic) 1810.1

Common amino acids L

Net charge 1

Instability index (II) 3.13

Aliphatic index 190.00

Grand average of hydropathicity (GRAVY) 1.750

Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 17561225

Title Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae)

Doi 10.1016/j.toxicon.2007.04.017

Year 2007

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available