Phylloseptin-L1
General Information
DCTPep ID DCTPep00186
Peptide Name Phylloseptin-L1
Sequence LLGMIPLAISAISALSKL
Sequence Length 18
UniProt ID A0A5Q0MU22 P0DQK9 L0P329
PubChem CID Not available
Origin skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae)
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
Cell Line | Disease | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|
Hep-G2 | Hepatoblastoma; Hepatoblastoma | LC50=35 μM | Cytolytic assays | 1 h | 1 |
Hemolytic Activity Human erythrocytes: LC50=200 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Cytolytic
Structure Information
PDB ID Not available
Predicted Structure DCTPep00186
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C84H151N19O22S1
Absent amino acids CDEFHNQRTVWY
Theoretical pI 8.75
Acidic residues 0
Basic residues 1
Polar residues 4
Molecular weight (Average) 1811.3
Molecular weight (Monoisotopic) 1810.1
Common amino acids L
Net charge 1
Instability index (II) 3.13
Aliphatic index 190.00
Grand average of hydropathicity (GRAVY) 1.750
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 17561225
Title Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae)
Doi 10.1016/j.toxicon.2007.04.017
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available