Phylloseptin-L1

General Information


DCTPep ID  DCTPep00186

Peptide Name   Phylloseptin-L1

Sequence  LLGMIPLAISAISALSKL

Sequence Length  18

UniProt ID  A0A5Q0MU22  P0DQK9  L0P329 

PubChem CID  Not available

Origin  skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae)

Type  Native peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
Hep-G2 Hepatoblastoma; Hepatoblastoma LC50=35 μM Cytolytic assays 1 h 1

Hemolytic Activity  Human erythrocytes: LC50=200 μM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Cytolytic



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00186

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C84H151N19O22S1

Absent amino acids  CDEFHNQRTVWY

Theoretical pI  8.75

Acidic residues  0

Basic residues  1

Polar residues  4

Molecular weight (Average)  1811.3

Molecular weight (Monoisotopic)  1810.1

Common amino acids  L

Net charge  1

Instability index (II)  3.13

Aliphatic index  190.00

Grand average of hydropathicity (GRAVY)  1.750

Half Life 
  5.5 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 17561225

Title  Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae)

Doi 10.1016/j.toxicon.2007.04.017

Year  2007

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.