DCTPep ID  DCTPep00210

Peptide Name   Ranatuerin-2Ya

Sequence  GLMDTIKGVAKTVAASWLDKLKCKITGC

Sequence Length  28

UniProt ID  Not available

PubChem CID  Not available

Origin  North America, leopard frog, Lithobates yavapaiensis

Type  Native peptide

Hemolytic Activity  Human erythrocytes: LD50>100 μM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  potent cytolytic activity

PDB ID  Not available

Predicted Structure  DCTPep00210

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Cys23<--->Cys28

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L

Grand average of hydropathicity (GRAVY)  0.343

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5625
  Abs 0.1% (=1 g/l) 1.906, assuming all pairs of Cys residues form cystines
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 1.863, assuming all Cys residues are reduced

Amino acid distribution

Literature 1

Pubmed ID 19254736

Title  Peptides with potent cytolytic activity from the skin secretions of the North American leopard frogs, Lithobates blairi and Lithobates yavapaiensis

Doi 10.1016/j.toxicon.2009.02.018

Year  2009

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available

DBAASP ID  DBAASPR_4218