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Pexiganan MSI-78
General Information
DCTPep ID DCTPep00266
Peptide Name Pexiganan MSI-78
Sequence GIGKFLKKAKKFGKAFVKILKK
Sequence Length 22
UniProt ID Not available
PubChem CID Not available
Origin Helical peptide with a predominance of one or more amino acids tryptophane-rich
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | 75% Cytotoxicity at 0.5 µg/ml | MTT assay | 6 h | 1 |
| OVCAR-3 | High grade ovarian serous adenocarcinoma | LC50=13 at 100 µM | MTS assay | 72 h | 3 |
| LNCaP | Prostate carcinoma | LC50=6 at 100 µM | MTS assay | 72 h | 3 |
| MCF-7 | Invasive breast carcinoma of no special type | LC50=8 at 100 µM | MTS assay | 72 h | 3 |
| BMKC | Skin carcinoma | LD50=140 µg/ml | MTT assay | 24 h | Patent |
| NCI-H1299 | Lung large cell carcinoma | LD50=150 µg/ml | MTT assay | 24 h | Patent |
| MCF-7 | Invasive breast carcinoma of no special type | LD50=31 µg/ml | MTT assay | 24 h | Patent |
| SW480 | Colon adenocarcinoma | LD50=34 µg/ml | MTT assay | 24 h | Patent |
| PC-3 | Prostate carcinoma | LD50=66 µg/ml | MTT assay | 24 h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00266
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C122H209N31O23
Absent amino acids CDEHMNPQRSTWY
Theoretical pI 10.90
Acidic residues 0
Basic residues 9
Polar residues 3
Molecular weight (Average) 2478.2
Molecular weight (Monoisotopic) 2476.61
Common amino acids K
Net charge 9
Instability index (II) -6.16
Aliphatic index 93.18
Grand average of hydropathicity (GRAVY) -0.159
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 21403917
Title Antitumor activity of antimicrobial peptides against U937 histiocytic cell line
Doi Not available
Year 2011
Literature 2
Pubmed ID 8573171
Title A novel antimicrobial peptide from Bufo bufo gargarizans
Year 1996
Literature 3
Pubmed ID 24587350
Title Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity
Doi 10.1371/journal.pone.0090397
Year 2014
Patent
Patent ID US2005/0209157A1
Patent Title Short bioactive peptides and methods for their use
Other Iinformation Patent Application; Family: 1s / 24ex; Family Jurisdictions: US; Legal Status: Discontinued; Application No: 13618605; Filed: May 24, 2005; Published: Sep 22, 2005; Earliest Priority: Mar 28, 2001
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.