T Peptide

General Information


DCTPep ID  DCTPep00498

Peptide Name   T Peptide

Sequence  TKPRKTKPRKTKPRKTKPR

Sequence Length  19

UniProt ID  Not available

PubChem CID  Not available

Origin  Tuftsin derivative

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
BGC-823 Human papillomavirus-related endocervical adenocarcinoma 67.2% maximum inhibitory rate at 8 mg/kg MTT assay 48 h 1
Hep-G2 Hepatoblastoma; Hepatoblastoma 69.6% maximum inhibitory rate at 8 mg/kg MTT assay 48 h 1
HT-29 Colon adenocarcinoma 70% maximum inhibitory rate at 8 mg/kg MTT assay 48 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00498

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C102H190N38O24

Absent amino acids  ACDEFGHILMNQSVWY

Theoretical pI  12.49

Acidic residues  0

Basic residues  11

Polar residues  4

Molecular weight (Average)  2332.87

Molecular weight (Monoisotopic)  2331.48

Common amino acids  K

Net charge  11

Instability index (II)  -22.27

Aliphatic index  0.00

Grand average of hydropathicity (GRAVY)  -2.868

Half Life 
  7.2 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 24714081

Title  Anticancer activity of tuftsin-derived T peptide in postoperative residual tumors

Doi 10.1097/CAD.0000000000000111

Year  2014

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.