This work is licensed under a Creative Commons Attribution 4.0 International License.
T Peptide
General Information
DCTPep ID DCTPep00498
Peptide Name T Peptide
Sequence TKPRKTKPRKTKPRKTKPR
Sequence Length 19
UniProt ID Not available
PubChem CID Not available
Origin Tuftsin derivative
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| BGC-823 | Human papillomavirus-related endocervical adenocarcinoma | 67.2% maximum inhibitory rate at 8 mg/kg | MTT assay | 48 h | 1 |
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | 69.6% maximum inhibitory rate at 8 mg/kg | MTT assay | 48 h | 1 |
| HT-29 | Colon adenocarcinoma | 70% maximum inhibitory rate at 8 mg/kg | MTT assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00498
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C102H190N38O24
Absent amino acids ACDEFGHILMNQSVWY
Theoretical pI 12.49
Acidic residues 0
Basic residues 11
Polar residues 4
Molecular weight (Average) 2332.87
Molecular weight (Monoisotopic) 2331.48
Common amino acids K
Net charge 11
Instability index (II) -22.27
Aliphatic index 0.00
Grand average of hydropathicity (GRAVY) -2.868
Half Life
7.2 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24714081
Title Anticancer activity of tuftsin-derived T peptide in postoperative residual tumors
Doi 10.1097/CAD.0000000000000111
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.