This work is licensed under a Creative Commons Attribution 4.0 International License.
Callyaerin A
General Information
DCTPep ID DCTPep00560
Peptide Name Callyaerin A
Sequence IXVILPPLXPIFG
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Callyspongia aerizusa
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| L5178Y | Mouse leukemia | ED50=3.61µM | MTT assay | 72h | 2 |
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | IC50=30µM; IC90=50µM | Resazurin assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity MRC-5:IC50=20µM; IC90=40µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond SMB: Ile1<--->X(9)
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X(2)= 4-Hydroxyproline; X(9)=Daa
Chiral L
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26213786
Title Callyaerins from the Marine Sponge Callyspongia aerizusa: Cyclic Peptides with Antitubercular Activity
Doi 10.1021/acs.jnatprod.5b00266
Year 2015
Literature 2
Pubmed ID 20599387
Title Callyaerins A-F and H, new cytotoxic cyclic peptides from the Indonesian marine sponge Callyspongia aerizusa
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.