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HPRP-A1
General Information
DCTPep ID DCTPep00577
Peptide Name HPRP-A1
Sequence FKKLKKLFSKLWNWK
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=3.5±0.03 μM | MTT assay | 24h | 1 |
| SGC-7901 | Human papillomavirus-related endocervical adenocarcinoma | IC50=5.2±0.14 μM | MTT assay | 24h | 1 |
| B16 | Mouse melanoma | IC50=6.1±0.02 μM | MTT assay | 24h | 1 |
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | IC50=7.7±0.23 μM | MTT assay | 24h | 1 |
Hemolytic Activity Human RBC: MHC=64±6.80 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00577
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C101H156N24O18
Absent amino acids ACDEGHIMPQRTVY
Theoretical pI 10.70
Acidic residues 0
Basic residues 6
Polar residues 2
Molecular weight (Average) 1994.5
Molecular weight (Monoisotopic) 1993.2
Common amino acids K
Net charge 6
Instability index (II) -6.23
Aliphatic index 78.00
Grand average of hydropathicity (GRAVY) -0.833
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 5.515
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26405806
Title TAT Modification of Alpha-Helical Anticancer Peptides to Improve Specificity and Efficacy
Doi 10.1371/journal.pone.0138911
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.