This work is licensed under a Creative Commons Attribution 4.0 International License.
Ctn(Crotalicidin)
General Information
DCTPep ID DCTPep00582
Peptide Name Ctn(Crotalicidin)
Sequence KRFKKFFKKVKKSVKKRLKK工FKKPMVIGVTIPF
Sequence Length 34
UniProt ID Not available
PubChem CID Not available
Origin Rattlesnake Venom Cathelicidin
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa S3 | Breast cancer | IC50 < 1 µM | Resazurin assay | 4h | 1 |
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | IC50 < 1 µM | Resazurin assay | 4h | 1 |
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | IC50=1.56 µM | Resazurin assay | 4h | 1 |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | IC50>12.5 µM | Resazurin assay | 4h | 1 |
| Jurkat E6.1 | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | IC50>12.5 µM | Resazurin assay | 4h | 1 |
Hemolytic Activity Human erythrocytes: 7% and 33% hemolysis at 100 and 400 μM, respectively
Normal (non-cancerous) Cytotoxicity MM6: IC50=3.12 µM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral Mix
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26465972
Title Structural Dissection of Crotalicidin, a Rattlesnake Venom Cathelicidin, Retrieves a Fragment with Antimicrobial and Antitumor Activity
Doi 10.1021/acs.jmedchem.5b01142
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.