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YR
General Information
DCTPep ID DCTPep00583
Peptide Name YR
Sequence YGFVMPRSGLWFR
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Spirulina (Arthrospira) platensis
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | IC50=104.05 μg/mL | MTT assay | 48h | 1 |
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | IC50=188.23 μg/mL | MTT assay | 48h | 1 |
| SGC-7901 | Human papillomavirus-related endocervical adenocarcinoma | IC50=247.32 μg/mL | MTT assay | 48h | 1 |
| HT-29 | Colon adenocarcinoma | IC50=446.72 μg/mL | MTT assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00583
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C78H110N20O16S1
Absent amino acids ACDEHIKNQT
Theoretical pI 10.84
Acidic residues 0
Basic residues 2
Polar residues 4
Molecular weight (Average) 1615.92
Molecular weight (Monoisotopic) 1614.81
Common amino acids FGR
Net charge 2
Instability index (II) 82.72
Aliphatic index 52.31
Grand average of hydropathicity (GRAVY) 0.085
Half Life
2.8 hours (mammalian reticulocytes, in vitro).
10 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 6990
Abs 0.1% (=1 g/l) 4.326
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26584028
Title Inhibitory effects of small molecular peptides from Spirulina (Arthrospira) platensis on cancer cell growth
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.