This work is licensed under a Creative Commons Attribution 4.0 International License.
ZXR-1
General Information
DCTPep ID DCTPep00594
Peptide Name ZXR-1
Sequence FKIGGFIKKLWRSKLA
Sequence Length 16
UniProt ID N0EAL3
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | IC50=141.7±12.2 µM | MTT assay | 6h | 1 |
| SACC-83 | Salivary gland adenoid cystic carcinoma | IC50=27.9±7.7 µM | MTT assay | 6h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=62.6±8.4 µM | MTT assay | 6h | 1 |
| PC-3 | Prostate carcinoma | IC50=69.1±1.6 µM | MTT assay | 6h | 1 |
| Huh-7 | Adult hepatocellular carcinoma; Adult hepatocellular carcinoma | IC50=77.9±0.9 µM | MTT assay | 6h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HEK293T: IC50=186.7±13.1 µM; WPMY-1: IC50=283.3±19.0 µM
Target Not available
Affinity Not available
Mechanism ZXR-1 could internalize into cells by endocytosis, target on mitochondria, and induce cell apoptosis
Structure Information
PDB ID Not available
Predicted Structure DCTPep00594
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C93H150N24O18
Absent amino acids CDEHMNPQTVY
Theoretical pI 11.33
Acidic residues 0
Basic residues 5
Polar residues 3
Molecular weight (Average) 1892.36
Molecular weight (Monoisotopic) 1891.16
Common amino acids K
Net charge 5
Instability index (II) 28.73
Aliphatic index 103.75
Grand average of hydropathicity (GRAVY) 0.087
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.906
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27207743
Title From a pro-apoptotic peptide to a lytic peptide: One single residue mutation
Doi 0.1016/j.bbamem.2016.05.012
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.