This work is licensed under a Creative Commons Attribution 4.0 International License.
ZXR-2
General Information
DCTPep ID DCTPep00595
Peptide Name ZXR-2
Sequence FKIGGFIKKLWRSLLA
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| PC-3 | Prostate carcinoma | IC50=14.2±0.5 µM | MTT assay | 2h | 1 |
| PC-3 | Prostate carcinoma | IC50=14.8±1.6 μM | MTT assay | 2h | 2 |
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | IC50=7.5±1.2 µM | MTT assay | 2h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=8.1±1.6 µM | MTT assay | 2h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=8.1±1.6 μM | MTT assay | 2h | 2 |
| Huh-7 | Adult hepatocellular carcinoma; Adult hepatocellular carcinoma | IC50=8.4±1.1 µm | MTT assay | 2h | 1 |
| SACC-83 | Salivary gland adenoid cystic carcinoma | IC50=9.9±1.7 µM | MTT assay | 2h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HEK293T: IC50=6.3±0.7 µM; WPMY-1: IC50=12.4±2.0 µM
Target Not available
Affinity Not available
Mechanism ZXR-2 could cause cell membrane lysis
Structure Information
PDB ID Not available
Predicted Structure DCTPep00595
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C93H149N23O18
Absent amino acids CDEHMNPQTVY
Theoretical pI 11.26
Acidic residues 0
Basic residues 4
Polar residues 3
Molecular weight (Average) 1877.35
Molecular weight (Monoisotopic) 1876.15
Common amino acids KL
Net charge 4
Instability index (II) 34.04
Aliphatic index 128.12
Grand average of hydropathicity (GRAVY) 0.569
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.930
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 27207743
Title From a pro-apoptotic peptide to a lytic peptide: One single residue mutation
Doi 0.1016/j.bbamem.2016.05.012
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.