FR8P

General Information


DCTPep ID  DCTPep00708

Peptide Name   FR8P

Sequence  FRRFFKWPRRFFKFF

Sequence Length  15

UniProt ID  Not available

PubChem CID  Not available

Origin  AMP

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma IC50=10.5 μM MTT assay 24h 1
DLD-1 Colon adenocarcinoma IC50=10.8 μM MTT assay 24h 1
Hep-G2 Hepatoblastoma; Hepatoblastoma IC50=4.2 μM MTT assay 24h 1
MDA-MB-231 Breast adenocarcinoma IC50=6.4 μM MTT assay 24h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00708

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C115H154N30O16

Absent amino acids  ACDEGHILMNQSTVY

Theoretical pI  12.48

Acidic residues  0

Basic residues  6

Polar residues  0

Molecular weight (Average)  2212.68

Molecular weight (Monoisotopic)  2211.22

Common amino acids  F

Net charge  6

Instability index (II)  60.64

Aliphatic index  0.00

Grand average of hydropathicity (GRAVY)  -0.580

Half Life 
  1.1 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  2 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 5500
  Abs 0.1% (=1 g/l) 2.486

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28483698

Title  Selective phenylalanine to proline substitution for improved antimicrobial and anticancer activities of peptides designed on phenylalanine heptad repeat

Doi 10.1016/j.actbio.2017.05.007

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.