This work is licensed under a Creative Commons Attribution 4.0 International License.
FR4, 8P
General Information
DCTPep ID DCTPep00711
Peptide Name FR4, 8P
Sequence FRRPFKWPRRFFKFF
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin AMP
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=13.8 μM | MTT assay | 24h | 1 |
| DLD-1 | Colon adenocarcinoma | IC50=15.3 μM | MTT assay | 24h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | IC50=15.4 μM | MTT assay | 24h | 1 |
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | IC50=5 μM | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00711
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C111H152N30O16
Absent amino acids ACDEGHILMNQSTVY
Theoretical pI 12.48
Acidic residues 0
Basic residues 6
Polar residues 0
Molecular weight (Average) 2162.62
Molecular weight (Monoisotopic) 2161.2
Common amino acids F
Net charge 6
Instability index (II) 86.32
Aliphatic index 0.00
Grand average of hydropathicity (GRAVY) -0.873
Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.543
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28483698
Title Selective phenylalanine to proline substitution for improved antimicrobial and anticancer activities of peptides designed on phenylalanine heptad repeat
Doi 10.1016/j.actbio.2017.05.007
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.