This work is licensed under a Creative Commons Attribution 4.0 International License.
tMP-C
General Information
DCTPep ID DCTPep00817
Peptide Name tMP-C
Sequence RKKRRQRRRLNLKALLAVAKKIL
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin wasp venom
Type Native peptide
Classification
ACP Tumor active peptide Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| NCI-H157 | Lung squamous cell carcinoma | IC50=2.79 μM | MTT assay | 24h | 1 |
| U-251MG | Astrocytoma | IC50=3.36 μM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=3.70 μM | MTT assay | 24h | 1 |
| MDA-MB-435S | Amelanotic melanoma | IC50=3.86 μM | MTT assay | 24h | 1 |
| PC-3 | Prostate carcinoma | IC50=3.86 μM | MTT assay | 24h | 1 |
Hemolytic Activity Horse erythrocytes: HC50=77.94 μM
Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=9.18 μM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00817
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C125H238N48O26
Absent amino acids CDEFGHMPSTWY
Theoretical pI 12.70
Acidic residues 0
Basic residues 11
Polar residues 1
Molecular weight (Average) 2829.57
Molecular weight (Monoisotopic) 2827.88
Common amino acids R
Net charge 11
Instability index (II) 107.82
Aliphatic index 127.39
Grand average of hydropathicity (GRAVY) -0.887
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29904274
Title Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.