R2PLx-22

General Information


DCTPep ID  DCTPep00840

Peptide Name   R2PLx-22

Sequence  GIMDTVKNAAKNLAGQLLDKLK 

Sequence Length  23

UniProt ID  Not available

PubChem CID  Not available

Origin  skin secretions of the pickerel frog (Rana palustris)

Type  Native peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
U-251MG Astrocytoma IC50=104.10 μM MTT assay 24h 1
MCF-7 Invasive breast carcinoma of no special type IC50=109.30 μM MTT assay 24h 1
PC-3 Prostate carcinoma IC50=283.90 μM MTT assay 24h 1
NCI-H157 Lung squamous cell carcinoma IC50=843.40 μM MTT assay 24h 1
MDA-MB-435S Amelanotic melanoma IC50=872.70 μM MTT assay 24h 1

Hemolytic Activity  Horse erythrocytes: Low haemolytic activity

Normal (non-cancerous) Cytotoxicity  HMEC-1: IC50=588.20 μM

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  Mix



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30279210

Title  A novel antimicrobial peptide, Ranatuerin-2PLx, showing therapeutic potential in inhibiting proliferation of cancer cells

Doi 10.1042/BSR20180710

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.