This work is licensed under a Creative Commons Attribution 4.0 International License.
R2PLx
General Information
DCTPep ID DCTPep00841
Peptide Name R2PLx
Sequence GIMDTVKNAAKNLAGQLLDKLKCKITAC
Sequence Length 29
UniProt ID Not available
PubChem CID Not available
Origin skin secretions of the pickerel frog (Rana palustris)
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MDA-MB-435S | Amelanotic melanoma | IC50=15.44 μM | MTT assay | 24h | 1 |
| U-251MG | Astrocytoma | IC50=16.14 μM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=20.19 μM | MTT assay | 24h | 1 |
| PC-3 | Prostate carcinoma | IC50=5.79 μM | MTT assay | 24h | 1 |
| NCI-H157 | Lung squamous cell carcinoma | IC50=5.90 μM | MTT assay | 24h | 1 |
Hemolytic Activity Horse erythrocytes: Moderate haemolytic activity
Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=79.50 μM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral Mix
Physicochemical Information
Formula Not Applicable
Absent amino acids Not Applicable
Theoretical pI Not Applicable
Acidic residues Not Applicable
Basic residues Not Applicable
Polar residues Not Applicable
Molecular weight (Average) Not Applicable
Molecular weight (Monoisotopic) Not Applicable
Common amino acids Not Applicable
Net charge Not Applicable
Instability index (II) Not Applicable
Aliphatic index Not Applicable
Grand average of hydropathicity (GRAVY) Not Applicable
Half Life
Not Applicable
Extinction coefficients
Not Applicable
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30279210
Title A novel antimicrobial peptide, Ranatuerin-2PLx, showing therapeutic potential in inhibiting proliferation of cancer cells
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.