This work is licensed under a Creative Commons Attribution 4.0 International License.
S-24-R2Plx
General Information
DCTPep ID DCTPep00842
Peptide Name S-24-R2Plx
Sequence GIMDTVKNAAKNLAGQLLDKLKCSITAC
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin skin secretions of the pickerel frog (Rana palustris)
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| MDA-MB-435S | Amelanotic melanoma | IC50=179.00 μM | MTT assay | 24h | 1 |
| U-251MG | Astrocytoma | IC50=278.30 μM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=316.90 μM | MTT assay | 24h | 1 |
| NCI-H157 | Lung squamous cell carcinoma | IC50=58.18 μM | MTT assay | 24h | 1 |
| PC-3 | Prostate carcinoma | IC50=792.60 μM | MTT assay | 24h | 1 |
Hemolytic Activity Horse erythrocytes: Low haemolytic activity
Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=1185.00 μM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep00842
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C124H219N35O39S3
Absent amino acids EFHPRWY
Theoretical pI 8.82
Acidic residues 2
Basic residues 4
Polar residues 9
Molecular weight (Average) 2920.49
Molecular weight (Monoisotopic) 2918.54
Common amino acids AKL
Net charge 2
Instability index (II) 6.81
Aliphatic index 108.21
Grand average of hydropathicity (GRAVY) 0.229
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.043, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30279210
Title A novel antimicrobial peptide, Ranatuerin-2PLx, showing therapeutic potential in inhibiting proliferation of cancer cells
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.