H193F

General Information


DCTPep ID  DCTPep00844

Peptide Name   H193F

Sequence  GCRLYGFKIFGCG

Sequence Length  13

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Cancer targeted peptides



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
Hep-G2 Hepatoblastoma; Hepatoblastoma IC50=26.8 µM CCK-8 assay 48h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Protein kinase CK2

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep00844

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys2<--->Cys12

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C65H97N17O15S2

Absent amino acids  ADEHMNPQSTVW

Theoretical pI  8.90

Acidic residues  0

Basic residues  2

Polar residues  7

Molecular weight (Average)  1420.71

Molecular weight (Monoisotopic)  1419.68

Common amino acids  G

Net charge  2

Instability index (II)  -15.39

Aliphatic index  60.00

Grand average of hydropathicity (GRAVY)  0.585

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 1615
  Abs 0.1% (=1 g/l) 1.137, assuming all pairs of Cys residues form cystines
  Ext. coefficient 1490
  Abs 0.1% (=1 g/l) 1.049, assuming all Cys residues are reduced

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30307134

Title  Structure-based Discovery of Novel CK2α-Binding Cyclic Peptides with Anti-cancer Activity

Doi 10.1002/minf.201800089

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.