Peptide Libraray

L187V

General Information

DCTPep ID DCTPep00848

Peptide Name L187V

Sequence GCRVYGFKIHGCG

Sequence Length 13

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Cancer targeted peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
Hep-G2	Hepatoblastoma; Hepatoblastoma	IC50=38.9 µM	CCK-8 assay	48h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Protein kinase CK2

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep00848

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond Cys2<--->Cys12

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C61H93N19O15S2

Absent amino acids ADELMNPQSTW

Theoretical pI 8.90

Acidic residues 0

Basic residues 3

Polar residues 7

Molecular weight (Average) 1396.65

Molecular weight (Monoisotopic) 1395.65

Common amino acids G

Net charge 3

Instability index (II) -19.68

Aliphatic index 52.31

Grand average of hydropathicity (GRAVY) 0.154

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 1615
Abs 0.1% (=1 g/l) 1.156, assuming all pairs of Cys residues form cystines
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 1.067, assuming all Cys residues are reduced

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 30307134

Title Structure-based Discovery of Novel CK2α-Binding Cyclic Peptides with Anti-cancer Activity

Doi 10.1002/minf.201800089

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available