DCTPep ID  DCTPep00921

Peptide Name   [R9S]cTI

Sequence  KWCFRVCYSGICYRRCRG

Sequence Length  18

UniProt ID  Not available

PubChem CID  Not available

Origin  host defense peptide from the horseshoe crab Tachypleus tridentatus

Type  Synthetic peptide

Hemolytic Activity  Human RBCs: CC50>64 µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

PDB ID  Not available

Predicted Structure  DCTPep00921

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys3<--->Cys16; Cys7<--->Cys12

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L

Grand average of hydropathicity (GRAVY)  -0.306

Half Life 
  1.3 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  3 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 8730
  Abs 0.1% (=1 g/l) 3.868, assuming all pairs of Cys residues form cystines
  Ext. coefficient 8480
  Abs 0.1% (=1 g/l) 3.758, assuming all Cys residues are reduced

Amino acid distribution

Literature 1

Pubmed ID 31714739

Title  Cyclic Analogues of Horseshoe Crab Peptide Tachyplesin I with Anticancer and Cell Penetrating Properties

Doi 10.1021/acschembio.9b00782

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available