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Cm-p5 [E4C, H8C]
General Information
DCTPep ID DCTPep00924
Peptide Name Cm-p5 [E4C, H8C]
Sequence SRSCLIVCQRLF
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Not active up to 300 µg/ml | PrestoBlue cell viability reagent | overnight | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys4<--->Cys8
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C61H105N19O16S2
Absent amino acids ADEGHKMNPTWY
Theoretical pI 9.01
Acidic residues 0
Basic residues 2
Polar residues 4
Molecular weight (Average) 1424.74
Molecular weight (Monoisotopic) 1423.74
Common amino acids CLRS
Net charge 2
Instability index (II) 91.69
Aliphatic index 121.67
Grand average of hydropathicity (GRAVY) 0.833
Half Life
1.9 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 125
Abs 0.1% (=1 g/l) 0.088, assuming all pairs of Cys residues form cystines
Ext. coefficient 0
Abs 0.1% (=1 g/l) 0.000, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 31763531
Title Design of a Helical-Stabilized, Cyclic, and Nontoxic Analogue of the Peptide Cm-p5 With Improved Antifungal Activity.
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.