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DAP1
General Information
DCTPep ID DCTPep01037
Peptide Name DAP1
Sequence LWKRWVGVWRKWL
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | IC50=11.9 µM | MTT assay | 48h | 1 |
| NCI/ADR-RES | High grade ovarian serous adenocarcinoma | IC50=14.0 µM | MTT assay | 48h | 1 |
| T24 | Bladder carcinoma | IC50=15.3 µM | MTT assay | 48h | 1 |
| OVCAR-3 | High grade ovarian serous adenocarcinoma | IC50=8.6 µM | MTT assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HUVEC: IC50=19.5 μM; NL20: IC50=19.0 μM
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01037
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C92H133N25O14
Absent amino acids ACDEFHIMNPQSTY
Theoretical pI 12.02
Acidic residues 0
Basic residues 4
Polar residues 1
Molecular weight (Average) 1813.23
Molecular weight (Monoisotopic) 1812.05
Common amino acids W
Net charge 4
Instability index (II) 93.02
Aliphatic index 104.62
Grand average of hydropathicity (GRAVY) -0.369
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 22000
Abs 0.1% (=1 g/l) 12.133
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33184577
Title Re-engineering Antimicrobial Peptides into Oncolytics Targeting Drug-Resistant Ovarian Cancers
Doi 10.1007/s12195-020-00626-z
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.