ND2

General Information


DCTPep ID  DCTPep01105

Peptide Name   ND2

Sequence  GLFDIVKGIKSLF

Sequence Length  13

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
Hep-G2 Hepatoblastoma; Hepatoblastoma IC50=72.00±4.51 µg/mL MTT assay 24h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Vero: IC50=48.67±1.76 µg/mL; THLE-3: IC50=58.83±0.83 µg/mL

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  DCTPep01105

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C70H113N15O17

Absent amino acids  ACEHMNPQRTWY

Theoretical pI  8.59

Acidic residues  1

Basic residues  2

Polar residues  3

Molecular weight (Average)  1436.76

Molecular weight (Monoisotopic)  1435.84

Common amino acids  FGIKL

Net charge  1

Instability index (II)  -9.62

Aliphatic index  142.31

Grand average of hydropathicity (GRAVY)  1.038

Half Life 
  30 hours (mammalian reticulocytes, in vitro).
  >20 hours (yeast, in vivo).
  >10 hours (Escherichia coli, in vivo).

Extinction coefficients 
  Should not be visible by UV spectrophotometry.

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Hybrid Anticancer Peptides DN1 and DN4 Exert Selective Cytotoxicity Against Hepatocellular Carcinoma Cells by Inducing Both Intrinsic and Extrinsic Apoptotic Pathways

Doi 10.1007/s10989-021-10288-8

Year  2021

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.