Peptide Libraray

DN4

General Information

DCTPep ID DCTPep01113

Peptide Name DN4

Sequence ILGKIWKGIVSDF

Sequence Length 13

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
Hep-G2	Hepatoblastoma; Hepatoblastoma	IC50=191.67±12.02 µg/mL	MTT assay	24h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Vero: IC50>256 µg/mL; THLE-3: IC50>256 µg/mL

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01113

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C72H114N16O17

Absent amino acids ACEHMNPQRTY

Theoretical pI 8.59

Acidic residues 1

Basic residues 2

Polar residues 3

Molecular weight (Average) 1475.79

Molecular weight (Monoisotopic) 1474.85

Common amino acids I

Net charge 1

Instability index (II) -14.41

Aliphatic index 142.31

Grand average of hydropathicity (GRAVY) 0.808

Half Life
20 hours (mammalian reticulocytes, in vitro).
30 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 3.727

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Hybrid Anticancer Peptides DN1 and DN4 Exert Selective Cytotoxicity Against Hepatocellular Carcinoma Cells by Inducing Both Intrinsic and Extrinsic Apoptotic Pathways

Doi 10.1007/s10989-021-10288-8

Year 2021

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available