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HYL-12
General Information
DCTPep ID DCTPep01202
Peptide Name HYL-12
Sequence GIMSSLMKKLAAHAAK
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin AMP
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | IC50 ＞50 µmol/L | MTT assay | 72h | Patent |
| HCT 116 | Colon carcinoma | IC50 ＞50 µmol/L | MTT assay | 72h | Patent |
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | IC50 ＞50 µmol/L | MTT assay | 72h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Human Splenic Fibroblasts (HSF): IC50=12.78±0.33 µg/mL; Endometrial epithelial cells(HEEC): IC50=2.66±0.34 µg/mL; HPDE6c7 Human Pancreatic Duct Epithelial Cell: IC50=3.45±0.20 µg/mL; Normal Human Hepatic Cell (Lo-2): IC50=2.91±0.07 µg/mL; NCM460: IC50=3.04±0.10 µg/mL; CCD-19Lu: IC50=4.76±0.03 µg/mL
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01202
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C72H129N21O19S2
Absent amino acids CDEFNPQRTVWY
Theoretical pI 10.30
Acidic residues 0
Basic residues 4
Polar residues 3
Molecular weight (Average) 1657.07
Molecular weight (Monoisotopic) 1655.92
Common amino acids A
Net charge 4
Instability index (II) 32.96
Aliphatic index 98.12
Grand average of hydropathicity (GRAVY) 0.388
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Structural modification and antitumor activity of antimicrobial peptide HYL
Doi 10.1016/j.cclet.2019.10.013
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.