Peptide Libraray

SEQ ID NO: 3

General Information

DCTPep ID DCTPep01799

Peptide Name SEQ ID NO: 3

Sequence LMYXTYLK

Sequence Length 8

UniProt ID Not available

PubChem CID Not available

Origin Synthetics

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
Hep-G2	Hepatoblastoma; Hepatoblastoma	When the peptide concentrations were 1 nM, 10 nM, 100 nM, and 1 μM, the Percent Cytotoxicity of the tumor was 12.3 ± 0.4, 10.7 ± 0.1, 9.5 ± 1.0, 6.9 ± 0.0	MTT assay	48 h	Patent
HEp-2	Human papillomavirus-related endocervical adenocarcinoma	When the peptide concentrations were 1 nM, 10 nM, 100 nM, and 1 μM, the Percent Cytotoxicity of the tumor was 12.6 ± 2.8, 15.4 ± 1.3, 13.9 ± 0.5, 10.8 ± 0.5	MTT assay	48 h	Patent
KB	Human papillomavirus-related endocervical adenocarcinoma	When the peptide concentrations were 1 nM, 10 nM, 100 nM, and 1 μM, the Percent Cytotoxicity of the tumor was 12.9 ± 1.3, 17.7 ± 0.5, 14.9 ± 1.1, 9.5 ± 0.1	MTT assay	48 h	Patent
PA-1	Ovarian mixed germ cell tumor; Mixed germ cell tumor	When the peptide concentrations were 1 nM, 10 nM, 100 nM, and 1 μM, the Percent Cytotoxicity of the tumor was 16.8 ± 1.4, 18.0 ± 1.8, 12.5 ± 0.0, 10.8 ± 0.6	MTT assay	48 h	Patent
Mia PaCa-2	Pancreatic ductal adenocarcinoma	When the peptide concentrations were 1 nM, 10 nM, 100 nM, and 1 μM, the Percent Cytotoxicity of the tumor was 21.8 ± 2.1, 24.0 ± 2.7, 17.9 ± 1.8, 13.9 ± 0.4	MTT assay	48 h	Patent

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification X=Saa2, furanoid sugar amino acid

Chiral L

Physicochemical Information

Formula Not Applicable

Absent amino acids Not Applicable

Theoretical pI Not Applicable

Acidic residues Not Applicable

Basic residues Not Applicable

Polar residues Not Applicable

Molecular weight (Average) Not Applicable

Molecular weight (Monoisotopic) Not Applicable

Common amino acids Not Applicable

Net charge Not Applicable

Instability index (II) Not Applicable

Aliphatic index Not Applicable

Grand average of hydropathicity (GRAVY) Not Applicable

Half Life
Not Applicable

Extinction coefficients
Not Applicable

Amino acid distribution

Literature Information

Literature 1

Pubmed ID Not available

Title Not available

Doi Not available

Year Not available

Patent

Patent ID US7060678B2

Patent Title Peptides comprising furanoid sugar amino acids for the treatment of cancer

Other Iinformation Granted Patent; Family: 2s / 2ex; Family Jurisdictions: US; Legal Status: Inactive; Application No: 63810703; Filed: Aug 8, 2003; Published: Jun 13, 2006; Earliest Priority: Aug 8, 2003; Granted: Jun 13, 2006

Other Published ID US7060678B2