Wollamide B [D-Orn6Orn]

General Information


DCTPep ID  DCTPep01856

Peptide Name   Wollamide B [D-Orn6Orn]

Sequence  NVlLWX

Sequence Length  6

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide Membrane-targeted



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
Hep-G2 Hepatoblastoma IC50=137.6 µM SRB assay Not available 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Vero cells: IC50=73.2 µg/ml

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: Asn1<--->X6

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  l=D-Leu; X=Orn

Chiral  Mix



Physicochemical Information


Formula  Not Applicable

Absent amino acids  Not Applicable

Theoretical pI  Not Applicable

Acidic residues  Not Applicable

Basic residues  Not Applicable

Polar residues  Not Applicable

Molecular weight (Average)  Not Applicable

Molecular weight (Monoisotopic)  Not Applicable

Common amino acids  Not Applicable

Net charge  Not Applicable

Instability index (II)  Not Applicable

Aliphatic index  Not Applicable

Grand average of hydropathicity (GRAVY)  Not Applicable

Half Life 
  Not Applicable

Extinction coefficients 
  Not Applicable

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 29125222

Title  Total Synthesis and Antibacterial Study of Cyclohexapeptides Desotamide B, Wollamide B and Their Analogs

Doi 10.1002/cbdv.201700414

Year  2018

Literature 2

Pubmed ID 29431987

Title  Solid-Phase Synthesis and Antibacterial Activity of Cyclohexapeptide Wollamide B Analogs

Doi 10.1021/acscombsci.7b00189

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DCTPep is developed by Dr.Zheng's team.