Peptide Libraray

Desotamide A

General Information

DCTPep ID DCTPep01857

Peptide Name Desotamide A

Sequence NGWLLI

Sequence Length 6

UniProt ID Not available

PubChem CID 10349738

Origin Streptomyces scopuliridis SCSIO ZJ46

Type Native peptide

Classification

Cancer therapy related peptides

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
Hep-G2	Hepatoblastoma	IC50>100 µM	SRB assay	Not available	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Cyclic

Disulfide/Other Bond NCB: Asn1<--->Ile6

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C35H54N8O8

Absent amino acids ACDEFHKMPQRSTVY

Theoretical pI 5.52

Acidic residues 0

Basic residues 0

Polar residues 2

Molecular weight (Average) 714.86

Molecular weight (Monoisotopic) 714.41

Common amino acids L

Net charge 0

Instability index (II) 24.42

Aliphatic index 195.00

Grand average of hydropathicity (GRAVY) 1.217

Half Life
1.4 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 7.694

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 25072108

Title Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria

Doi 10.1021/np500399v

Year 2014

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPN_11147