Peptide Libraray

LL37 (14-21)+Indolicidin (5-13), LI

General Information

DCTPep ID DCTPep01918

Peptide Name LL37 (14-21)+Indolicidin (5-13), LI

Sequence GKEFKRIVKWPWWPWRR

Sequence Length 17

UniProt ID P49913 P33046

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide Membrane-targeted

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
Hep-G2	Hepatoblastoma	87.5% Killing=128µM	MTT assay	20-24 h	1

Hemolytic Activity Human erythrocytes: 5%Hemolysis>128 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep01918

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C117H167N33O20

Absent amino acids ACDHLMNQSTY

Theoretical pI 11.73

Acidic residues 1

Basic residues 6

Polar residues 1

Molecular weight (Average) 2355.82

Molecular weight (Monoisotopic) 2354.31

Common amino acids W

Net charge 5

Instability index (II) 38.37

Aliphatic index 40.00

Grand average of hydropathicity (GRAVY) -1.435

Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 22000
Abs 0.1% (=1 g/l) 9.339

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 29282543

Title Characterization of bactericidal efficiency, cell selectivity, and mechanism of short interspecific hybrid peptides

Doi 10.1007/s00726-017-2531-1

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_11172