This work is licensed under a Creative Commons Attribution 4.0 International License.
LL37 (14-21)+NP-1 (23-31), LN
General Information
DCTPep ID DCTPep01919
Peptide Name LL37 (14-21)+NP-1 (23-31), LN
Sequence GKEFKRIVGRIYRLCCR
Sequence Length 17
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide Membrane-targeted
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma | 80% Killing=128µM | MTT assay | 20-24 h | 1 |
Hemolytic Activity Human erythrocytes: 5%Hemolysis>128 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01919
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C92H157N31O21S2
Absent amino acids ADHMNPQSTW
Theoretical pI 10.31
Acidic residues 1
Basic residues 6
Polar residues 5
Molecular weight (Average) 2097.57
Molecular weight (Monoisotopic) 2096.16
Common amino acids R
Net charge 5
Instability index (II) -5.18
Aliphatic index 85.88
Grand average of hydropathicity (GRAVY) -0.388
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1615
Abs 0.1% (=1 g/l) 0.770, assuming all pairs of Cys residues form cystines
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.710, assuming all Cys residues are reduced
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29282543
Title Characterization of bactericidal efficiency, cell selectivity, and mechanism of short interspecific hybrid peptides
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_11173
This work is licensed under a Creative Commons Attribution 4.0 International License.