This work is licensed under a Creative Commons Attribution 4.0 International License.
CRAMP (20-35)[G4W][K8R]
General Information
DCTPep ID DCTPep01926
Peptide Name CRAMP (20-35)[G4W][K8R]
Sequence KKIWQKIKRFFQKL
Sequence Length 14
UniProt ID P51437
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma | EC50>50µM | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep01926
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C93H151N25O17
Absent amino acids ACDEGHMNPSTVY
Theoretical pI 11.39
Acidic residues 0
Basic residues 6
Polar residues 0
Molecular weight (Average) 1891.38
Molecular weight (Monoisotopic) 1890.17
Common amino acids K
Net charge 6
Instability index (II) 8.31
Aliphatic index 83.57
Grand average of hydropathicity (GRAVY) -0.964
Half Life
1.3 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
3 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.908
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30176261
Title Structure-activity relationship study of the antimicrobial CRAMP-derived peptide CRAMP20-33
Doi 10.1016/j.peptides.2018.08.013
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_12503
This work is licensed under a Creative Commons Attribution 4.0 International License.