PL-D 6

General Information


DCTPep ID  DCTPep02224

Peptide Name   PL-D 6

Sequence  KRWWKWWRR

Sequence Length  9

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

ACP Tumor active peptide



Activity Information


Cell Line Disease Activity Assay Testing Time Literature
THP-1 Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia IC50=79.2 µM Resazurin assay 72 h 2

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available



Structure Information


PDB ID  Not available

Predicted Structure  Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C74H102N24O10

Absent amino acids  ACDEFGHILMNPQSTVY

Theoretical pI  12.31

Acidic residues  0

Basic residues  5

Polar residues  0

Molecular weight (Average)  1487.78

Molecular weight (Monoisotopic)  1486.82

Common amino acids  W

Net charge  5

Instability index (II)  172.4

Aliphatic index  0.00

Grand average of hydropathicity (GRAVY)  -2.767

Half Life 
  1.3 hours (mammalian reticulocytes, in vitro).
  3 min (yeast, in vivo).
  3 min (Escherichia coli, in vivo).

Extinction coefficients 
  Ext. coefficient 22000
  Abs 0.1% (=1 g/l) 14.787

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 23478953

Title  Targeting Mycobacterium tuberculosis and other microbial pathogens using improved synthetic antibacterial peptides

Doi 10.1128/AAC.00175-13

Year  2013

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_7047

DCTPep is developed by Dr.Zheng's team.