This work is licensed under a Creative Commons Attribution 4.0 International License.
PL-D 23
General Information
DCTPep ID DCTPep02241
Peptide Name PL-D 23
Sequence LKRRWKWWI
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | IC50=186.7 µM | Resazurin assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C69H102N20O10
Absent amino acids ACDEFGHMNPQSTVY
Theoretical pI 12.02
Acidic residues 0
Basic residues 4
Polar residues 0
Molecular weight (Average) 1371.7
Molecular weight (Monoisotopic) 1370.81
Common amino acids W
Net charge 4
Instability index (II) 162.97
Aliphatic index 86.67
Grand average of hydropathicity (GRAVY) -1.244
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 16500
Abs 0.1% (=1 g/l) 12.029
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23478953
Title Targeting Mycobacterium tuberculosis and other microbial pathogens using improved synthetic antibacterial peptides
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_7068
This work is licensed under a Creative Commons Attribution 4.0 International License.