Peptide Libraray

PL-D 37

General Information

DCTPep ID DCTPep02255

Peptide Name PL-D 37

Sequence RRWRVIVKW

Sequence Length 9

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

ACP Tumor active peptide

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
THP-1	Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia	IC50=197.2 µM	Resazurin assay	72 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure Not available

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C62H99N21O10

Absent amino acids ACDEFGHLMNPQSTY

Theoretical pI 12.30

Acidic residues 0

Basic residues 4

Polar residues 0

Molecular weight (Average) 1298.6

Molecular weight (Monoisotopic) 1297.79

Common amino acids R

Net charge 4

Instability index (II) 123.54

Aliphatic index 107.78

Grand average of hydropathicity (GRAVY) -0.700

Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 8.471

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 23478953

Title Targeting Mycobacterium tuberculosis and other microbial pathogens using improved synthetic antibacterial peptides

Doi 10.1128/AAC.00175-13

Year 2013

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available

External Code

DBAASP ID DBAASPS_7082