This work is licensed under a Creative Commons Attribution 4.0 International License.
PL-D 46
General Information
DCTPep ID DCTPep02264
Peptide Name PL-D 46
Sequence RTKKWIVWI
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | IC50=208.3 µM | Resazurin assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C61H96N16O11
Absent amino acids ACDEFGHLMNPQSY
Theoretical pI 11.17
Acidic residues 0
Basic residues 3
Polar residues 1
Molecular weight (Average) 1229.53
Molecular weight (Monoisotopic) 1228.74
Common amino acids IKW
Net charge 3
Instability index (II) -0.54
Aliphatic index 118.89
Grand average of hydropathicity (GRAVY) -0.178
Half Life
1 hours (mammalian reticulocytes, in vitro).
2 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 11000
Abs 0.1% (=1 g/l) 8.947
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23478953
Title Targeting Mycobacterium tuberculosis and other microbial pathogens using improved synthetic antibacterial peptides
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_7091
This work is licensed under a Creative Commons Attribution 4.0 International License.