Peptide Libraray

PLS-S2

General Information

DCTPep ID DCTPep02320

Peptide Name PLS-S2

Sequence FLSLIPHIVSGVASLAKHF

Sequence Length 19

UniProt ID Not available

PubChem CID Not available

Origin Phyllomedusa sauvagii

Type Native peptide

Classification

ACP Tumor active peptide Membrane lysis

Activity Information

Cell Line	Disease	Activity	Assay	Testing Time	Literature
THP-1	Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia	IC50=22.5 µM	MTT assay	72 h	1

Hemolytic Activity Human erythrocytes: LC50=25 µM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Structure Information

PDB ID Not available

Predicted Structure DCTPep02320

(Please note that there is the predicted structure, predicted by AlphaFold)

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C98H154N24O23

Absent amino acids CDEMNQRTWY

Theoretical pI 8.76

Acidic residues 0

Basic residues 3

Polar residues 4

Molecular weight (Average) 2036.45

Molecular weight (Monoisotopic) 2035.16

Common amino acids LS

Net charge 3

Instability index (II) 21.16

Aliphatic index 143.68

Grand average of hydropathicity (GRAVY) 1.226

Half Life
1.1 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).

Extinction coefficients
Should not be visible by UV spectrophotometry.

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 23967105

Title Structure, antimicrobial activities and mode of interaction with membranes of novel [corrected] phylloseptins from the painted-belly leaf frog, Phyllomedusa sauvagii

Doi 10.1371/journal.pone.0070782

Year 2013

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available