This work is licensed under a Creative Commons Attribution 4.0 International License.
SK84
General Information
DCTPep ID DCTPep02362
Peptide Name SK84
Sequence SQLGDLGSGAGQGGGGGGSIRAAGGAFGKLEAAREEEFFYKKQKEQLERLKNDQIHQAEFHHQQIKEHEEAIQRHKDFLNNLHK
Sequence Length 84
UniProt ID B4LLX1
PubChem CID Not available
Origin Drosophila virilis
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | IC50=35 µM | MTS assay | 72 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=50 µM | MTS assay | 72 h | 1 |
| HepG2 | Hepatoblastoma | IC50=92 µM | MTS assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02362
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C406H632N128O127
Absent amino acids CMPTVW
Theoretical pI 6.57
Acidic residues 13
Basic residues 18
Polar residues 20
Molecular weight (Average) 9338.27
Molecular weight (Monoisotopic) 9332.69
Common amino acids G
Net charge 5
Instability index (II) 45.46
Aliphatic index 60.60
Grand average of hydropathicity (GRAVY) -1.093
Half Life
1.9 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.160
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 19799950
Title Isolation, characterization and anti-cancer activity of SK84, a novel glycine-rich antimicrobial peptide from Drosophila virilis
Doi 10.1016/j.peptides.2009.09.028
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPR_4323
This work is licensed under a Creative Commons Attribution 4.0 International License.