This work is licensed under a Creative Commons Attribution 4.0 International License.
CEN1 HC (1–20)
General Information
DCTPep ID DCTPep02887
Peptide Name CEN1 HC (1–20)
Sequence GWFKKTFHKVSHAVKSGIHA
Sequence Length 20
UniProt ID D8WN02
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer therapy related peptides
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Weak active up to 125 mg/L | MTT assay | 6 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure DCTPep02887
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C107H161N31O24
Absent amino acids CDELMNPQRY
Theoretical pI 10.48
Acidic residues 0
Basic residues 7
Polar residues 5
Molecular weight (Average) 2265.65
Molecular weight (Monoisotopic) 2264.23
Common amino acids K
Net charge 7
Instability index (II) 22.4
Aliphatic index 58.50
Grand average of hydropathicity (GRAVY) -0.355
Half Life
30 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 5500
Abs 0.1% (=1 g/l) 2.428
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23237525
Title Anti-infectious and anti-inflammatory effects of peptide fragments sequentially derived from the antimicrobial peptide centrocin 1 isolated from the green sea urchin, Strongylocentrotus droebachiensis
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_17826
This work is licensed under a Creative Commons Attribution 4.0 International License.