This work is licensed under a Creative Commons Attribution 4.0 International License.
Phakellistatin 5
General Information
DCTPep ID DCTPep02939
Peptide Name Phakellistatin 5
Sequence AIPFNAM
Sequence Length 7
UniProt ID Not available
PubChem CID 11115315
Origin Phakellia costada
Type Native peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| DU145 | Prostate carcinoma | GI50=0.14-0.74 μg/mL | Not available | Not available | 1 |
| KM20L2 | Colon adenocarcinoma | GI50=0.14-0.74 μg/mL | Not available | Not available | 1 |
| NCI-H460 | Lung large cell carcinoma | GI50=0.14-0.74 μg/mL | Not available | Not available | 1 |
| OVCAR-3 | High grade ovarian serous adenocarcinoma | GI50=0.14-0.74 μg/mL | Not available | Not available | 1 |
| P388 | Mouse lymphoma | GI50=0.14-0.74 μg/mL | Not available | Not available | 1 |
| SF295 | Glioblastoma | GI50=0.14-0.74 μg/mL | Not available | Not available | 1 |
| SK-MEL-5 | Cutaneous melanoma | GI50=0.14-0.74 μg/mL | Not available | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Ala1<--->Met7
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C35H54N8O9S1
Absent amino acids CDEGHKLQRSTVWY
Theoretical pI 5.57
Acidic residues 0
Basic residues 0
Polar residues 1
Molecular weight (Average) 762.92
Molecular weight (Monoisotopic) 762.37
Common amino acids A
Net charge 0
Instability index (II) 31.97
Aliphatic index 84.29
Grand average of hydropathicity (GRAVY) 1.100
Half Life
4.4 hours (mammalian reticulocytes, in vitro).
>20 hours (yeast, in vivo).
>10 hours (Escherichia coli, in vivo).
Extinction coefficients
Should not be visible by UV spectrophotometry.
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 10650072
Title Synthesis of the marine sponge cycloheptapeptide phakellistatin 5(1)
Year 2000
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.