This work is licensed under a Creative Commons Attribution 4.0 International License.
SEQ ID NO.01 of Patent CN 113234128A
General Information
DCTPep ID DCTPep06005
Peptide Name SEQ ID NO.01 of Patent CN 113234128A
Sequence LLRHVVKILKYLHGVSGHGQHGVHG
Sequence Length 25
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
ACP Tumor active peptide
Activity Information
| Cell Line | Disease | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | IC50=10.25μM | CCK-8 assay | 48h | Patent |
| HepG2 | Hepatoblastoma | IC50=10.82μM | CCK-8 assy | 48h | Patent |
| BGC-823 | Human papillomavirus-related endocervical adenocarcinoma | IC50=13.61μM | CCK-8 assay | 48h | Patent |
| MCF-7 | Invasive breast carcinoma of no special type | IC50=13.98μM | CCK-8 assay | 48h | Patent |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | IC50=8.345μM | CCK-8 assay | 48h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Structure Information
PDB ID Not available
Predicted Structure Not available
(Please note that there is the predicted structure, predicted by AlphaFold)
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C125H201N41O29
Absent amino acids ACDEFMNPTW
Theoretical pI 10.29
Acidic residues 0
Basic residues 8
Polar residues 7
Molecular weight (Average) 2742.23
Molecular weight (Monoisotopic) 2740.55
Common amino acids GH
Net charge 8
Instability index (II) 8.18
Aliphatic index 124.40
Grand average of hydropathicity (GRAVY) 0.024
Half Life
5.5 hours (mammalian reticulocytes, in vitro).
3 min (yeast, in vivo).
2 min (Escherichia coli, in vivo).
Extinction coefficients
Ext. coefficient 1490
Abs 0.1% (=1 g/l) 0.543
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID CN113234128A
Patent Title Anti-tumor active polypeptide and application thereof
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.